Hyaluronic Acid May Not Be Good For Cancer
It has be found that usually cancer drugs fail because they cannot penetrate the high-pressure environment of solid tumors. Biophysical Journal published a study that reveals large, naturally occurring molecule called hyaluronic acid is primarily responsible for generating elevated gel-fluid pressures in tumors. Treatment with an enzyme that breaks down hyaluronic acid normalized fluid pressure in tumors and allows vessels to re-expand, overcomes a major barrier to drug delivery in a mouse model of pancreatic cancer.
The gel-fluid phase generates a primary mechanism of drug resistance in pancreas cancer, according to the senior study author Sunil Hingorani
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