Scientists Use CRISPR To Reverse Engineer Brain Cancer Cells

A team of scientists at the University of Toronto has successfully used CRISPR-Cas9 technology to determine likely targets for glioblastoma (GBM). This type of cancer is one of the most aggressive, having only a few existing treatment solutions. GBM is also the leading cause of cancer-related deaths in children and young adults.

Gene by gene, the strategy used genome editing to effectively reverse engineer metastatic, patient-derived GBM stem cells. In addition, it was able to mark genes that are crucial for tumor development. Apart from highlighting several possible GBM targets, the research offered new insights into the basis of …read more